Hydroxypinacolone Retinoate
Hydroxypinacolone Retinoate (HPR) is a next-generation, esterified form of retinoic acid — the active form of Vitamin A that directly binds to retinoid receptors in the skin. Unlike other retinol derivatives that require multiple conversion steps in the skin, HPR acts directly at the receptor level, delivering the benefits of traditional retinoids with significantly less irritation.
HPR is known for its effectiveness in improving skin texture, reducing signs of aging, targeting acne, and promoting a more even, radiant complexion. It is often marketed as a gentle yet potent alternative to retinoic acid and retinol, making it suitable for individuals who are sensitive to traditional retinoids. It is commonly found in anti-aging serums, creams, and corrective treatments.
❓What It Does in Skincare
- Stimulates collagen production to improve skin firmness and reduce fine lines and wrinkles.
- Promotes cell turnover, helping to refine texture and smooth rough or uneven skin.
- Improves pigmentation irregularities and fades dark spots by accelerating skin renewal.
- Helps treat and prevent acne by normalising skin shedding and reducing clogged pores.
- Delivers similar benefits to prescription-strength retinoids without the typical redness, dryness, or flaking.
- Works more efficiently than traditional retinol, as it does not require conversion to retinoic acid in the skin.
🧬Safety & Toxicology
- Considered one of the most well-tolerated retinoid derivatives, suitable for most skin types including sensitive and reactive skin.
- Lower risk of irritation compared to retinol and tretinoin, though mild sensitivity may still occur in some users.
- Should be introduced gradually, especially for first-time retinoid users.
- Not recommended during pregnancy or breastfeeding due to its Vitamin A activity.
- Sun protection is essential while using HPR, as it may increase photosensitivity.
- Non-toxic when used topically in cosmetic concentrations and supported by clinical research for long-term use.